propofol line change

  • Physicochemical compatibility and emulsion stability of

    Conclusions Propofol should not be administered with 4-hydroxybutyric acid, remifentanil hydrochloride, midazolam hydrochloride and piritramide through the same intravenous line. Based on the risk of sorption to the rubber material, propofol should be used with caution. A drug loss might occur that leads to an underdosing of the patient requiring a dose adjustment to avoid any adverse

  • Propofol Anesthesiology American Society of

    Propofol is a unique compound compared to the other intravenous anesthetics. It is a simple phenol substituted with two isopropyl groups in each of the positions adjacent to the hydroxyl group, the ortho positions ().In its pure form at room temperature, it is an oil

  • Propofol Anesthesia and Cerebral Blood Flow Changes

     · First, propofol tended to reduce the absolute global CBF as its concentration increased, except for the deepest level of anesthesia, where we observed an increase in CBF. Second, propofol reduced in a dose-dependent manner normalized rCBF in specific brain regions including the thalamus and several cortical regions.

  • propofol infusion ONLY through central lineMICU / SICU

     · Oct 26, 2006. At one time the Society of Critical Care Medicine (SCCM) guidelines for propofol infusion specified the use of a central vein. In 2002, however, a revision was made which did not include that requirement the revision did include mention of a dedicated line.

  • Propofol for Treatment of Acute Migraine in the Emergency

     · Based on the available evidence, propofol is a reasonable last-line or salvage therapy, especially for refractory or intractable migraine patients or in patients who have contraindications to multiple first-line abortive therapies. There may, however, still be significant clinical feasibility issues related to its use.

  • Administration Set ChangePedagogy

    Propofol Primary Set Replace tubing used to administer propofol infusions every 6 or 12 hours, when the vial is changed, per the manufacturer's recommendation. 1 A dedicated administration set should be used and should be replaced every 12 hours when the vial is changed, and according to the manufacturer's directions for use. 2

  • Statement on Safe Use of Propofol American Society of

     · Due to the potential for rapid, profound changes in sedative/anesthetic depth and the lack of antagonist medications, agents such as propofol require special attention. Even if moderate sedation is intended, patients receiving propofol should receive care consistent with that required for deep sedation.

  • Effects of Propofol on Hippocampal Synaptic Transmission

    Previous studies of the effects of propofol on synaptic transmission have been conducted mainly in vitro , 10–12during circumstancesin which the anesthetic dose of propofol can only be inferred. Two major studies have evaluated the effects of propofol in vivo .In one study, 13urethane was administered before the effects of propofol were evaluated.

  • Propofol compatibility with other intravenous drug

    Result Of the 77 drugs tested, 69 showed immediate evidence of physical change, and the other 8 were found incompatible within 72 hours. Conclusions Practitioners should not mix the immediately incompatible products with propofol by administering them in the same intravenous line. Caution should be used in simultaneous administration of the

  • Propofol Induces Postoperative Depression and Inhibits

     · Many patients experience excellent physical recoveries after surgery however, there are some of them who from suffer mood fluctuation, even depression. Postoperative depression may be resulted from cognitive dysfunction, pain, and a compromised immune system during the surgery. But there is a higher possibility that general anaesthesia may be responsible for the development of

  • Green Urine after Propofol Infusion in the Intensive Care

     · Urine discoloration occurs in the intensive care unit (ICU) due to many causes such as medications, metabolic disorders, and infections. Propofol is advocated as one of the first line sedatives in the ICU, but it is not well known to the intensivists that propofol can induce urine color change. We experienced two cases of green urine after propofol infusion. Propofol should be warranted as the

  • Propofol Induces Postoperative Depression and Inhibits

     · Many patients experience excellent physical recoveries after surgery however, there are some of them who from suffer mood fluctuation, even depression. Postoperative depression may be resulted from cognitive dysfunction, pain, and a compromised immune system during the surgery. But there is a higher possibility that general anaesthesia may be responsible for the development of

  • Propofol for Treatment of Acute Migraine in the Emergency

     · Based on the available evidence, propofol is a reasonable last-line or salvage therapy, especially for refractory or intractable migraine patients or in patients who have contraindications to multiple first-line abortive therapies. There may, however, still be significant clinical feasibility issues related to its use.

  • The effect of propofol on haemodynamics cardiac output

     · An increase in propofol concentration within the therapeutic range causes a decrease in vascular stressed volume without a change in CO. The absence of an effect of propofol on CO can be explained by the balance between the decrease in effective, or stressed, volume (as determined by MSFP), the decrease in resistance for venous return, and

  • Propofol modulates inhibitory inputs in paraventricular

     · One-minute baseline and one-minute propofol affected currents (8 or 9 min after propofol) were analyzed. In dissecting the effect of picrotoxin on propofol-induced change in holding currents, neurons in PVT were recorded in hte voltage-clamp mode

  • Propofol Dosing GuidelinesStanford University

     · B. Reduce propofol doses by 40 60% for elderly patients, sick patients, or following a heavy premed. II. Maintenance A. Check repeatedly that the infusion is running. Continuous infusions are prone to equipment problems, such as the clamps left on the line, running out of drug, excessive backpressure in the line

  • Propofol regulates the expression of TLR4 through miR‑21

    Introduction. Propofol (2,6-diisopropylphenol) belongs to phenol derivatives and its biosynthesis dates back to the 1970s ().Propofol is one of the most commonly used intravenous anesthetics at present (2–4).However, several reports have shown that anesthetics, including propofol, can inhibit the stress response during surgery and exert adverse effects on the immune system (5–7).

  • Emulsion Stability of Different Intravenous Propofol

    Background Propofol and remifentanil often need to be co-administered via the same intravenous catheter line, which predisposes to potential compatibility issues. Our aim was to determine and compare the emulsion stability of three propofol formulations, two with medium chain triglycerides and one with long chain triglycerides, when administered together with remifentanil hydrochloride

  • Emulsion Stability of Different Intravenous Propofol

    In the case of propofol, an incompatibility can be revealed by a change in the emulsion droplet size. An increase in the content of large sized oil droplets (>5 µm) may become critical (exceed the acceptable safety limit) long before it is possible to visually detect emulsion destabilisation.

  • Haemodynamic changes during propofol induction in dogs

     · Propofol is one of the most widely used injectable anaesthetic agents in veterinary practice. Cardiovascular effects related to propofol use in dogs remain less well defined. The main objective of this study was to evaluate the haemodynamic changes during induction of general anaesthesia with propofol in healthy dogs, by a beat-to-beat continuous monitoring.

  • Propofol Review of Potential Risks During Administration

     · propofol infusion.25 A high incidence of lipemia, hyper-triglyceridemia, and fatty liver changes have also been noted after prolonged propofol infusion.23,26 Risk factors Figure 2. Stopcock (A) and Inline Injection Port (B) Containing Residual Propofol (red arrow) Table. Recommendations for Handling and Administration of Propofol

  • Extension set change with propofol tubing IV-Therapy

     · Some brands of propofol need Some brands of propofol need to have set changed every 6 hours, others every 12 h. I am a strong proponent of extension sets on all PIVCs. I am assuming your are asking about infusion through PIVC.

  • Propofol and arrhythmias two sides of the coin Acta

     · The H9c2 cell line was established from an embryonic rat cardiac ventricle, Therefore, it was thought that the conductance change was an indirect effect of propofol.

  • Propofol C12H18OPubChem

    Propofol is subject to oxidative degradation when exposed to oxygen. Intact containers are packaged using nitrogen to avoid oxygen exposure. if propofol is administered directly from the vial, administration should be completed within 12 hours after the vial is spiked. If Propofol emulsion is transferred to a syringe or other container prior to use, administration should be begun promptly and completed within

  • Does anyone change their propofol tubing Q24h?General

     · My facility has a protocol for 12 hour tubing change. The 12 hour tubing change is based on the propofol manufacturer. Propofol labeling indicates EDTA has been added to prevent microbial growth for up to 12 hours. I would look at your propofol labeling and see what your propofol

  • Practice guidelines for propofol sedation by non

     · Introduction. Because of the favorable pharmacokinetic profile of propofol (i.e., rapid onset of action and short recovery time), it has been widely used for sedation by practitioners across a broad range of specialties.In contrast to the agents used for traditional sedation (i.e., benzodiazepines and/or opioids), propofol can easily lead to deep sedation or even general anesthesia requiring

  • Propofol for Treatment of Acute Migraine in the Emergency

     · Based on the available evidence, propofol is a reasonable last-line or salvage therapy, especially for refractory or intractable migraine patients or in patients who have contraindications to multiple first-line abortive therapies. There may, however, still be significant clinical feasibility issues related to its use.

  • Guidelines for the safe practice of total intravenous

     · Estimated plasma concentrations (solid line) achieved with alternating infusion rates (dashed line) of 10 and 20 ml.h −1 1% propofol, in a 70 kg adult without a bolus dose (Marsh model). The concentrations change slowly and do not reach concentrations usually associated with

  • Propofol MedLink Neurology

     · Propofol, a short-acting, non-barbiturate hypnotic for intravenous use, was developed in the United Kingdom in 1970s but was withdrawn from the market due to solubility issues and anaphylactic reactions. An improved emulsion formulation of propofol was introduced under the brand name Diprivan (diisopropyl intravenous anesthetic) in 1986.

  • Quiet the storm Propofol for ventricular arrhythmias

     · Limited studies show that propofol can effectively manage ventricular dysrhythmias refractory to first-line antiarrhythmic. Before we examine this closely, let’s review some of the causes of electrical storm In one case report, a 62-year-old male presented to the ED with generalized weakness, nausea, vomiting, palpitations, and dyspnea.

  • Propofol‐Associated Hypertriglyceridemia and Pancreatitis

    Propofol was discontinued within 24 hours of detecting the hypertriglyceridemia 84% of the time. Compared with those who did not develop hypertriglyceridemia, patients who developed hypertriglyceridemia were older, had a longer intensive care unit stay, and received propofol for a longer duration they were also more likely to be admitted to